Bioautomation

Volume 22, Issue 4
Special Issue on Advanced Biosensors and Biomedical Signals Guest Editor: Huawei Liang, Henan Polytechnic University
Application of Fiber Optic Biosensor in Detection of Sports Analeptic	301-314
Yong Liu
doi: 10.7546/ijba.2018.22.4.301-314
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Yong Liu (2018) Application of Fiber Optic Biosensor in Detection of Sports Analeptic, Int J Bioautomation, 22 (4), 301-314, doi: 10.7546/ijba.2018.22.4.301-314
Abstract: To improve the efficiency and accuracy of analeptic detection in competitive sports, a new kind of optical fiber biosensor is proposed. The competition law and the ligand binding theory are applied, and according to the combination proportion of competitive molecular of analeptic molecules and its fluorescence labeled in the receptor, the information of analeptic molecular content is transformed into fluorescence signal intensity. The results showed that the lowest concentration of the estrogen and androgen that can be detected by the fiber optic biosensor is 10^-9 mol/L; physical response time is less than 0.1 seconds; the system error for repeating the experiment is less than 0.25%; agarose SAMs can be saved more than 30 d at -4 ºC light avoidance condition. It is concluded that the sensor has good reliability, accuracy, stability and repeatability as well as high sensitivity so that it is especially suitable for the screening detection of analeptic. Keywords: Fiber optical biosensor, Analeptic, Fluorescence labeling
Biomedical Signal Acquisition of Hepatobiliary and Portal Vein Before and After Exercise	315-324
Xinshi Zhao
doi: 10.7546/ijba.2018.22.4.315-324
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Xinshi Zhao (2018) Biomedical Signal Acquisition of Hepatobiliary and Portal Vein Before and After Exercise, Int J Bioautomation, 22 (4), 315-324, doi: 10.7546/ijba.2018.22.4.315-324
Abstract: In clinical medicine, the research on the hepatobiliary system was proved successfully. In the field of sports medicine, there was little knowledge about the morphological changes, blood distribution, physiological and biochemical as well as pathological changes in the liver, gallbladder and portal vein during exercise. Therefore, studying the function of hepatobiliary system in sports was a problem worthy of attention in sports medicine, and it was also a scientific field that should be urgently studied. Taking exercise-induced abdominal pain as an example, in exercise-induced abdominal pain, the right upper abdominal pain was mainly caused by changes in liver, gallbladder and portal vein. Based on sports medicine, there was little research on the liver, gallbladder and portal vein systems, and the incidence of right upper abdominal pain during exercise was high. The actual mechanism and etiology of the disease still needed to be further confirmed. For this reason, this sports discomfort became the focus of this study. In addition, a safe and effective color Doppler instrument was used to measure the liver and gallbladder and portal vein. The liver, gallbladder and portal vein data before and after exercise were recorded. Based on preliminary experiments and practical results of small samples, it was demonstrated that the liver was ischemic during exercise. It is concluded that this study can lay a foundation for the future research on the liver and biliary portal system, and it is expected to provide safe, non-invasive, reliable, and new indicators for the medical supervision of sports medicine. Keywords: Before and after exercise, Liver, Gallbladder, Portal vein, Color Doppler ultrasound
Design of Human Motion Signal Gathering System Based on USB 2.0	325-336
Yongheng Bai
doi: 10.7546/ijba.2018.22.4.325-336
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Yongheng Bai (2018) Design of Human Motion Signal Gathering System Based on USB 2.0, Int J Bioautomation, 22 (4), 325-336, doi: 10.7546/ijba.2018.22.4.325-336
Abstract: In order to design a human motion signal acquisition system, through the virtual hardware platform, the firmware and the driver program of the data acquisition system are designed, so it can run in computers with Windows 7 and Lab Windows/CVI platform. At the same time, the 12-bit A/D conversion chip with high sampling rate and high precision is used for A/D conversion circuit design. In addition, the multi-channel technology is used to realize A/D conversion of multiplexing signal, which improves the measurement accuracy of the system. The results showed that this research implemented the advantages of USB 2.0 interface, improved the data serial transmission speed and met the high data throughput requirements. To sum up, the system achieves the design of human motion signal acquisition system with high efficiency, convenience, low cost and high-performance price ratio. Keywords: Human motion signal, USB 2.0, A/D conversion
Application of Graphene FET Nucleic Acid Biosensor in Human Motion Measurement	337-348
Hang Yin
doi: 10.7546/ijba.2018.22.4.337-348
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Hang Yin (2018) Application of Graphene FET Nucleic Acid Biosensor in Human Motion Measurement, Int J Bioautomation, 22 (4), 337-348, doi: 10.7546/ijba.2018.22.4.337-348
Abstract: In order to explore the application of graphene field effect transistor (FET) nucleic acid biosensor, the sensitivity and selectivity of nano FET biosensor detection are improved by the large physical surface ratio, high electron mobility, excellent thermo conductivity and high mechanical strength. The nano-material graphene is applied to the field effect transistor biosensor, and the FET biosensor based on graphene is constructed. In addition, target molecules with specific probes are immobilized on the surface of graphene. The purpose of detecting nucleic acid molecules with high sensitivity and high selectivity can be achieved by detecting the change of electrical signals before and after hybridization and using nucleic acid – nucleic acid molecules hybridization. At the same time, the DNA biosensor can be reused. The reduced graphene oxide (R-GO) field effect transistor DNA biosensor constructed has high sensitivity, high selectivity and reusability. The research results showed that it has a potential application prospect in human motion measurement as a detection tool. To sum up, graphene FET nucleic acid biosensor is suitable for being used in human motion measurement. Keywords: Graphene FET nucleic acid biosensor, Human motion measurement, Sensitivity
Application of Graphene Nanocomposite in Motion Sensing of Human Body	349-362
Dong Han, Yingxue Chen
doi: 10.7546/ijba.2018.22.4.349-362
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Dong Han, Yingxue Chen (2018) Application of Graphene Nanocomposite in Motion Sensing of Human Body, Int J Bioautomation, 22 (4), 349-362, doi: 10.7546/ijba.2018.22.4.349-362
Abstract: For exploring the application of graphene nano-composite, graphene is combined with other nano-materials to develop a new graphene nano-composite with high conductivity, good biocompatibility and strong affinity for enzymes, which improved the working performance of sensors in human motion sensing. Graphene oxide (GO) is prepared by using Hummers and offeman methods, and graphene is prepared from graphene oxide with glucose as a reducing agent. On the basis of electro-deposition of Prussian blue chitosan (PB-CS) film modified gold electrode, a new nano material graphene is introduced, and glucose oxidase as a model enzyme, a glucose biosensor based on RGO/PB-CS nano-composite is constructed. The research results showed that the sensor constructed has higher sensitivity, lower detection limit and smaller apparent Michaelis constant. To sum up, the combination of graphene and Prussian blue chitosan effectively promoted the electron transfer between the electrode surface and the analytical substrate, and improved the working performance of the sensor, which has potential application value in human motion sensing. Keywords: Graphene nano-composite, Human body, Motion sensing, Biosensors

Sponsored by National Science Fund of Bulgaria, Grant No DNP 06-18/2017